Molecular cytogenetic delineation of the critical deleted region in the 5q- syndrome.

@article{Jaju1998MolecularCD,
  title={Molecular cytogenetic delineation of the critical deleted region in the 5q- syndrome.},
  author={Rina J. Jaju and Jackie Boultwood and Francisco Javier Oliver and Markus Kostrzewa and Carrie Fidler and Nicholas R Parker and John D. McPherson and Stephan W. Morris and Ulrich Mueller and J Stephen Wainscoat and Lyndal Kearney},
  journal={Genes, chromosomes & cancer},
  year={1998},
  volume={22 3},
  pages={251-6}
}
The 5q- syndrome is a distinct type of myelodysplastic syndrome (MDS) characterised by refractory anaemia, morphological abnormalities of megakaryocytes, and del(5q) as the sole cytogenetic abnormality. In contrast to patients with therapy-related MDS with 5q deletions, 5q- syndrome patients have a favourable prognosis and a low rate of transformation to acute leukaemia. We have previously delineated a common deleted region of 5.6 Mb between the gene for fibroblast growth factor acidic (FGF1… CONTINUE READING
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