Molecular cytogenetic analysis of recurrent unbalanced t(11;17) in neuroblastoma.

  title={Molecular cytogenetic analysis of recurrent unbalanced t(11;17) in neuroblastoma.},
  author={R. Stallings and P. Carty and L. McArdle and M. Mullarkey and M. McDermott and F. Breatnach and A. O’Meara},
  journal={Cancer genetics and cytogenetics},
  volume={154 1},
Loss of 11q material occurs in approximately 30% of advanced stage neuroblastoma and defines a distinct genetic subtype of this disease. These tumors almost always possess unbalanced gain of the 17q, along with many additional recurrent chromosomal imbalances. Loss of 11q and gain of 17q is often the consequence of an unbalanced translocation between the long arms of both chromosomes, but because of the involvement of other chromosomal mechanisms, the actual frequency of t(11;17) is unknown. In… Expand
Origin and functional significance of large-scale chromosomal imbalances in neuroblastoma
  • R. Stallings
  • Biology, Medicine
  • Cytogenetic and Genome Research
  • 2007
The origin of chromosome imbalances in neuroblastoma.
Analysis of chromosome breakpoints in neuroblastoma at sub‐kilobase resolution using fine‐tiling oligonucleotide array CGH
2p24 Gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma: biological and clinical characteristics.
Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q− Neuroblastoma
Are chromosomal imbalances important in cancer?


Molecular analysis of chromosome arm 17q gain in neuroblastoma
Are gains of chromosomal regions 7q and 11p important abnormalities in neuroblastoma?
der(11)t(11;17): a distinct cytogenetic pathway of advanced stage neuroblastoma (NBL) - detected by spectral karyotyping (SKY).
Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma.
Coordinate deletion of chromosome 3p and 11q in neuroblastoma detected by comparative genomic hybridization.
Deletions in chromosome arms 3p and 11q are new prognostic markers in localized and 4s neuroblastoma.