Molecular cytogenetic analysis of follicular lymphoma (FL) provides detailed characterization of chromosomal instability associated with the t(14;18)(q32;q21) positive and negative subsets and histologic progression.

@article{Nanjangud2007MolecularCA,
  title={Molecular cytogenetic analysis of follicular lymphoma (FL) provides detailed characterization of chromosomal instability associated with the t(14;18)(q32;q21) positive and negative subsets and histologic progression.},
  author={Gouri J Nanjangud and Pulivarthi H. Rao and Julie Teruya-Feldstein and Ginger Donnelly and Jing Qin and Sukvarsha Mehra and Suresh C. Jhanwar and Andrew D. Zelenetz and Raju S. K. Chaganti},
  journal={Cytogenetic and genome research},
  year={2007},
  volume={118 2-4},
  pages={337-44}
}
We analyzed a cohort of 61 follicular lymphomas (FL) with an abnormal G-banded karyotype by spectral karyotyping (SKY) to better define the chromosome instability associated with the t(14;18)(q32;q21) positive and negative subsets of FL and histologic grade. In more than 70% of the patients, SKY provided additional cytogenetic information and up to 40% of the structural abnormalities were revised. The six most frequent breakpoints in both SKY and G-banding analyses were 14q32, 18q21, 3q27, 1q11… CONTINUE READING