Molecular cytogenetic analysis of archival uveal melanoma with known clinical outcome.

@article{Mensink2008MolecularCA,
  title={Molecular cytogenetic analysis of archival uveal melanoma with known clinical outcome.},
  author={Hanneke Willemijn Mensink and Emine Kiliç and Jolanda Vaarwater and Hannie J C W Douben and Dion A Paridaens and Annelies J E M M de Klein},
  journal={Cancer genetics and cytogenetics},
  year={2008},
  volume={181 2},
  pages={108-11}
}
Uveal melanoma (UM) is the most common primary intraocular tumor in the Western world. Cytogenetically, this tumor is characterized by typical chromosomal aberrations such as loss of 1p, 3, and 6q, and gain of 6p and 8q. Routinely, karyotyping and fluorescent in situ hybridization (FISH) on fresh tumor-biopsies are used to identify chromosomal changes. In addition, archival UM samples can be examined using comparative genomic hybridization (CGH). In the presented study, we used CGH on a series… CONTINUE READING