Molecular cryo-electron tomography of vitreous tissue sections: current challenges.

  title={Molecular cryo-electron tomography of vitreous tissue sections: current challenges.},
  author={Lars P O Norl{\'e}n and Ozan Oktem and Ulf Skoglund},
  journal={Journal of microscopy},
  volume={235 3},
Electron tomography of vitreous tissue sections (tissue TOVIS) allows the study of the three-dimensional structure of molecular complexes in a near-native cellular context. Its usage is, however, limited by an unfortunate combination of noisy and incomplete data, by a technically demanding sample preparation procedure, and by a disposition for specimen degradation during data collection. Here we outline some major challenges as experienced from the application of TOVIS to human skin. We further… CONTINUE READING

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