Molecular crowding increases the amplification success of multiple displacement amplification and short tandem repeat genotyping.

@article{Ballantyne2006MolecularCI,
  title={Molecular crowding increases the amplification success of multiple displacement amplification and short tandem repeat genotyping.},
  author={Kaye N. Ballantyne and Roland A. H. van Oorschot and R. J. Mitchell and Irene Koukoulas},
  journal={Analytical biochemistry},
  year={2006},
  volume={355 2},
  pages={298-303}
}
Multiple displacement amplification (MDA) can generate large quantities of genomic DNA product from small amounts of template. We investigated the ability of MDA to amplify samples containing very small amounts of target DNA (5 pg to 1 ng) in the presence of a second, larger DNA sample for downstream short tandem repeat (STR) multiplex genotyping. We… CONTINUE READING