Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma

Abstract

The histopathological and molecular heterogeneity of glioblastomas represents a major obstacle for effective therapies. Glioblastomas do not develop autonomously, but evolve in a unique environment that adapts to the growing tumour mass and contributes to the malignancy of these neoplasms. Here, we show that patient-derived glioblastoma xenografts generated… (More)
DOI: 10.18632/oncotarget.7454

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