Molecular cross-talk between the transcription, translation, and nonsense-mediated decay machineries.

  title={Molecular cross-talk between the transcription, translation, and nonsense-mediated decay machineries.},
  author={Francisco J. Iborra and Alexandre E Escargueil and Kon Yew Kwek and Alexandre V Akoulitchev and Peter R. Cook},
  journal={Journal of cell science},
  volume={117 Pt 6},
It is widely believed that translation occurs only in the cytoplasm of eukaryotes, but recent results suggest some takes place in nuclei, coupled to transcription. Support for this heterodoxy comes from studies of the nonsense-mediated decay (NMD) pathway; this pathway probably uses ribosomes to proofread messenger RNAs. We find components of the machineries involved in transcription, translation and NMD colocalise, interact and copurify, and that interactions between them are probably mediated… CONTINUE READING


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