Molecular credentialing of rodent bladder carcinogenesis models.

  title={Molecular credentialing of rodent bladder carcinogenesis models.},
  author={Paul D. Williams and Jae K. Lee and Dan Theodorescu},
  volume={10 8},
Cancer of the urinary bladder is often a result of exposure to chemical carcinogens. Models of this disease have been developed by exposing rodents to N-butyl-N-(4-hydroxybutyl)-nitrosamine (OH-BBN). The resultant tumors are histologically similar to human disease, but little is known about genetic similarities to the latter. Such knowledge would help identify or corroborate genes found important in human bladder cancer and suggest biologically appropriate mechanistic studies. We address this… CONTINUE READING