Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.

@article{Lu2007MolecularCO,
  title={Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.},
  author={Ling Lu and Qian Zhang and Valeriy Timofeyev and Zhao Zhang and J. Nilas Young and Hee-sup Shin and Anne A Knowlton and Nipavan Chiamvimonvat},
  journal={Circulation research},
  year={2007},
  volume={100 1},
  pages={112-20}
}
Cytoskeletal proteins are known to sculpt the structural architecture of cells. However, their role as bridges linking the functional crosstalk of different ion channels is unknown. Here, we demonstrate that a small conductance Ca(2+)-activated K(+) channels (SK2 channel), present in a variety of cells, where they integrate changes in intracellular Ca(2+) concentration [Ca(2+)(i)] with changes in K(+) conductance and membrane potential, associate with L-type Ca(2+) channels; Ca(v)1.3 and Ca(v)1… CONTINUE READING
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