Molecular correlates of impaired prefrontal plasticity in response to chronic stress.

@article{Kuipers2003MolecularCO,
  title={Molecular correlates of impaired prefrontal plasticity in response to chronic stress.},
  author={Sjoukje D. Kuipers and Andrea Trentani and Johan A. den Boer and Gert J. ter Horst},
  journal={Journal of neurochemistry},
  year={2003},
  volume={85 5},
  pages={1312-23}
}
Disturbed adaptations at the molecular and cellular levels following stress could represent compromised neural plasticity that contributes to the pathophysiology of stress-induced disorders. Evidence illustrates atrophy and cell death of stress-vulnerable neurones in the prefrontal cortex. Reduced plasticity may be realized through the destabilized function of selective proteins involved in organizing the neuronal skeleton and translating neurotrophic signals. To elucidate the mechanisms… CONTINUE READING
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