Molecular composition of GABAC receptors

@article{Enz1998MolecularCO,
  title={Molecular composition of GABAC receptors},
  author={Ralf Enz and Garry R. Cutting},
  journal={Vision Research},
  year={1998},
  volume={38},
  pages={1431-1441}
}

Figures from this paper

GABAA ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety
TLDR
It is suggested that GABAA ρ receptors may have a role in the amygdaloid modulation of fear and anxiety.
Electrophysiology of ionotropic GABA receptors
TLDR
The diversity of GABAA receptors widens the neuronal repertoire of responses to external signals and contributes to shaping the electrical activity of neurons and other cell types.
GABAB-Receptor Agonist-Based Immunotherapy for Type 1 Diabetes in NOD Mice
TLDR
Lesogaberan treatment temporarily restored normoglycemia in most newly diabetic NOD mice and analysis of microarray and RNA-Seq databases suggested that the expression of GABAB-Rs and GABAA-Rs, as well as GABA production/secretion-related genes, may be a more common feature of immune cells than currently recognized.
Inhibition of GABAA-ρ receptors induces retina regeneration in zebrafish
TLDR
The results support a model in which decreased levels of GABA, such as would occur after retinal cell death or damage, induce dedifferentiation of MG and the generation of proliferating progenitor cells during zebrafish retina regeneration.
The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family
TLDR
The functional consequences of sequence divergence and conservation are discussed, with special emphasis on the hair cell α9α10 receptor, a seemingly distant cousin of neuronal and muscle nicotinic receptors.
Anxiety-related circuitry in affective neuroscience
1Faculty of Medicine and Health Sciences, Universiti Sultan Zainal Abidin, Kuala, 21300, Terengganu, Malaysia 2Faculty of Informatics and Computing, Universiti Sultan Zainal Abidin, Besut Campus,
Pharmacological characterisation of GABA receptors in potential spinal cord neural stem cells
TLDR
Results indicate that modulation of GABA receptors by midazolam occurred at both CBR and TSPO, suggesting a potential involvement ofCBR and another receptor, Translocator Protein, indicating a further role for GABAB receptors on ependymal cells.
The Human Connectome: Functional Anatomy of the Brain
In this chapter there is a detailed description of the functional anatomy of the human brain, from the molecular and cellular level up to the production of higher cognitive function. The description
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans
TLDR
An up-to-date review on the currently available GABAA receptor subtype-selective ligands and proposals for the future development of ligands with better anxioselectivity in humans are made.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 125 REFERENCES
Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.
TLDR
Cloning of two rat GABA receptor subunits after their previously identified human homologues reveals the molecular mechanism underlying PTX blockade of GABA receptors but also the heteromeric nature of native receptors in the rat retina that underlie the PTX-resistant GABAC response.
Cloning of the kaminobutyric acid (GABA) z 1 cDNA: a GABA receptor subunit highly expressed in the retina
  • Proc Natl Acad Sci
  • 1991
Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells
TLDR
GABA gates bicuculline- and baclofen-insensitive GABA receptors in rod bipolar cells of the rat retina were activated selectively by the GABA analogue cis-4-aminocrotonic acid (CACA) and may be similar to those receptors termed GABAC receptors.
Aminobutyric acid A or C receptor? k-Aminobutyric acid z1 receptor RNA induces bicuculline- , barbiturate-and benzodiazepine-insensitive kaminobutyric acid responses in Xenopus oocytes
  • Mol Pharmacol
  • 1992
The N-terminal Domain of Human GABA Receptor ρ1 Subunits Contains Signals for Homooligomeric and Heterooligomeric Interaction*
TLDR
The N-terminal regions of ρ subunits contain the initial signals for both homooligomeric and heterooligomersic assembly into receptors with GABAC properties, suggesting that signals for ρ1 homooligenic assembly reside in the N- terminus of the subunit.
A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.
TLDR
Findings demonstrate that an amino acid in the putative channel domain of GABA rho 1 receptors influences picrotoxin sensitivity and mediates agonist binding by an allosteric mechanism.
Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat.
TLDR
The results support the idea that rho subunits are part of the GABAc receptor, and use of the polymerase chain reaction with reverse-transcribed total RNA from different brain tissues revealed that transcript for the rho 1 subunit was present in the retina only.
Sequences in the Amino Termini of GABA ρ and GABAA Subunits Specify Their Selective Interaction In Vitro
TLDR
Results indicate that sequences in the N termini direct assembly of ρ subunits and GABAA subunits into GABAC andGABAA receptors, respectively.
A comparison of GABAC and rho subunit receptors from the white perch retina.
TLDR
It is concluded that native GABAC receptors probably consist of a mixture of GABA rho subunits, and that perch-s receptors expressed by this gene in Xenopus oocytes show properties similar to those of the GABac receptors present on white perch retinal neurons.
Immunocytochemical Localization of the GABACReceptor ρ Subunits in the Mammalian Retina
TLDR
Polyclonal antibodies against the N terminus of the rat ρ1 subunit were generated to study the distribution of GABAC receptors in the mammalian retina and showed the punctate immunofluorescence to colocalize with bipolar cell axon terminals.
...
1
2
3
4
5
...