Molecular components of the B-cell antigen receptor complex of the IgM class

@article{Hombach1990MolecularCO,
  title={Molecular components of the B-cell antigen receptor complex of the IgM class},
  author={Joachim Hombach and Takeshi Tsubata and Lise Leclercq and Heike Stappert and Michael Reth},
  journal={Nature},
  year={1990},
  volume={343},
  pages={760-762}
}
THE antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes1,2 whose cross-linking by polyvalent antigens results in B-cell proliferation and differentiation3. How these membrane-bound immunoglobulin chains, which lack a cytoplasmic tail, generate a cell activation signal is not at present known. We now show… CONTINUE READING