Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

@article{Malpartida1984MolecularCO,
  title={Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host},
  author={Francisco Malpartida and David A. Hopwood},
  journal={Nature},
  year={1984},
  volume={309},
  pages={462-464}
}
The application of molecular cloning to antibiotic-producing microorganisms should lead to enhanced antibiotic productivity and to the biosynthesis of novel antibiotics by in vitro interspecific recombination1,2. To allow such approaches, the genes for antibiotic synthesis must be isolated, analysed and perhaps modified. Certain Streptomyces species produce nearly two-thirds of the known natural antibiotics3; the recent development of cloning systems in the genus4–7 makes it possible to isolate… CONTINUE READING
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