Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.

@article{Taira1993MolecularCO,
  title={Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.},
  author={Masanori Taira and Steven C. Hockman and J. Carlos Calvo and Per Belfrage and Vincent C. Manganiello},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 25},
  pages={18573-9}
}
Two distinct but related cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI PDE) cDNAs were cloned from rat adipose tissue cDNA libraries. The open reading frame (3324 base pairs) of RcGIP1 encodes 1108 amino acids, including a hydrophobic membrane-associated domain in the NH2-terminal portion and, in the COOH-terminal portion, a putative catalytic domain conserved among all mammalian PDEs which is preceded by a putative regulatory domain that contains three consensus cAMP-dependent… CONTINUE READING