Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila.

  title={Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila.},
  author={Daniel F. Woods and Peter J. Bryant},
  journal={Developmental biology},
  volume={134 1},
We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila. Mutations in this gene cause the imaginal discs to grow by cell proliferation beyond their normal final size, transform into solid tumors, fuse with one another and the brain, and lose their ability to differentiate. The oncogene represents the only known complementation group between two deficiency breakpoints, and 15 recessive lethal alleles are… CONTINUE READING