Molecular cloning of the human histamine H1 receptor gene.

  title={Molecular cloning of the human histamine H1 receptor gene.},
  author={Hirokazu Fukui and Kohei Fujimoto and Hiroyuki Mizuguchi and Kazuichi Sakamoto and Yoshiyuki Horio and Sinichiro Takai and Kouji Yamada and Satoru Ito},
  journal={Biochemical and biophysical research communications},
  volume={201 2},
The human histamine H1 receptor gene, an intron-lacking gene, was isolated with bovine H1 receptor cDNA [Yamashita, M., Fukui, H., Sugama, K., Horio, Y., Ito, S., Mizuguchi, H., and Wada, H. (1991) Proc. Natl. Acad. Sci. USA 88, 11515-11519] used as a probe. The receptor protein deduced from the nucleotide sequence of this gene was composed of 487 amino acid residues with a calculated Mr of 55,781 and possessed characteristic properties of GTP binding protein-coupled receptors. At the 5… CONTINUE READING
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