Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.

@article{Kato1990MolecularCO,
  title={Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.},
  author={Nobuyuki Kato and Makoto Hijikata and Yuko Ootsuyama and Masanori Nakagawa and Showgo Ohkoshi and Takashi Sugimura and Kunitada Shimotohno},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 24},
  pages={9524-8}
}
The nucleotide sequence of the Japanese type of hepatitis C virus (HCV-J) genome, consisting of 9413 nucleotides, was determined by analyses of cDNA clones from plasma specimens from Japanese patients with chronic hepatitis. HCV-J genome contains a long open reading frame that can encode a sequence of 3010 amino acid residues. Comparison of HCV-J with the American isolate of HCV showed 22.6% difference in nucleotide sequence and 15.1% difference in amino acid sequence. Thus HCV-J and the… CONTINUE READING
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