Molecular cloning of the human alpha 2(IX) collagen cDNA and assignment of the human COL9A2 gene to chromosome 1.

@article{Perl1993MolecularCO,
  title={Molecular cloning of the human alpha 2(IX) collagen cDNA and assignment of the human COL9A2 gene to chromosome 1.},
  author={Merja Per{\"a}l{\"a} and Milla M H{\"a}nninen and Johanna H{\"a}stbacka and Kati Elima and E. Vuorio},
  journal={FEBS letters},
  year={1993},
  volume={319 1-2},
  pages={177-80}
}
Type IX collagen, a heterotrimer of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chains, is a cartilage-specific fibril-associated collagen. In the process of characterizing genomic clones for the mouse alpha 2(IX) collagen gene four pairs of oligonucleotide primers designed for amplification of murine exon sequences were also utilized to construct cDNA clones for human alpha 2(IX) collagen spanning > 90% of the coding region. The amino acid and nucleotide sequence identities between human and… CONTINUE READING