Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.

  title={Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.},
  author={W A Sewell and Marion H Brown and Jack Dunne and Michael J Owen and Michael J. Crumpton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 22},
CD2 (T11, sheep erythrocyte receptor) is a surface antigen of the human T-lymphocyte lineage. cDNA clones encoding CD2 have been isolated by using the purified, denatured CD2 to raise a rat antiserum. Positive clones were recognized in a phage lambda gt11 expression library prepared from the human leukemia T-cell line J6. The DNA sequence contained an open reading frame encoding 360 amino acids. The N-terminal 24 amino acids were characteristic of a signal peptide and were followed by a region… CONTINUE READING


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