Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.

@article{Langmann1999MolecularCO,
  title={Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.},
  author={Thomas Langmann and Jochen Klucken and Markus Reil and Gerhard Liebisch and M F Luciani and Giovanna Chimini and W E Kaminski and Gerd Schmitz},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={257 1},
  pages={29-33}
}
We have cloned the full-length cDNA for the human ATP binding cassette transporter 1 (hABC1). The 6603-bp open reading frame encodes a polypeptide of 2201 amino acids resulting in a deduced molecular weight of 220 kDa. The hABC1 cDNA is highly homologous (62%) to the human rim ABC transporter (ABCR). hABC1 is expressed in a variety of human tissues with highest expression levels found in placenta, liver, lung, adrenal glands, and fetal tissues. We demonstrate that the hABC1 expression is… CONTINUE READING
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