Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.

@article{Chong1993MolecularCO,
  title={Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.},
  author={Samuel S Chong and Kristleifur Kristj{\'a}nsson and Huda Y. Zoghbi and Mark R. Hughes},
  journal={Genomics},
  year={1993},
  volume={18 2},
  pages={355-9}
}
Resorption of phosphate by the kidney is an important function in the maintenance of phosphate homeostasis in mammals, and a defect in renal phosphate uptake has been implicated in at least three human genetic disorders. We have isolated a cDNA encoding a human sodium-dependent phosphate transport protein (NPT1). This cDNA hybridizes to a single 2.5-kb RNA transcript from human kidney cortex, its nucleotide sequence shows 80.3% identity to the rabbit NaPi-1 sequence, and it encodes a… CONTINUE READING