Molecular cloning of the alpha-globin transcription factor CP2.

  title={Molecular cloning of the alpha-globin transcription factor CP2.},
  author={L C Lim and Steven L Swendeman and M Sheffery},
  journal={Molecular and cellular biology},
  volume={12 2},
CP2, a transcription factor that binds the murine alpha-globin promoter, was purified and subjected to amino acid sequence analysis. Oligonucleotide primers derived from the sequence were used to obtain murine and human cDNA clones for the factor. The murine cDNA spans approximately 4 kb and contains two coextensive open reading frames (ORFs) which encode deduced polypeptides of 529 (ORF-1; molecular weight, 59,802) and 502 (ORF-2; molecular weight, 56,957) amino acids, slightly smaller than… CONTINUE READING


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