Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats.

Abstract

We cloned the full-length rat leptin receptor (Ob-R) isoform complementary DNAs (cDNAs) and examined the gene expression in rats. We also identified a mutation in Ob-R in Zucker fatty (fa/fa) rats. Three alternatively spliced isoforms (Ob-Ra, Ob-Rb, and Ob-Re) have been identified, which are closely related to the gp130 signal-transduction component of… (More)

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@article{Takaya1996MolecularCO, title={Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats.}, author={Kai Takaya and Y. Ogawa and Naohi Isse and T. Okazaki and N. Satoh and Hiroaki Masuzaki and Keiichiro Mori and N. Tamura and Kazutaka Hosoda and Kentaro Nakao}, journal={Biochemical and biophysical research communications}, year={1996}, volume={225 1}, pages={75-83} }