Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system.

@article{Kobayashi1993MolecularCO,
  title={Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system.},
  author={Hideki Kobayashi and Yuushi Uchida and Yasuo Ihara and Kazunori Nakajima and Shinichi Kohsaka and Tadashi Miyatake and Shoji Tsuji},
  journal={Brain research. Molecular brain research},
  year={1993},
  volume={19 3},
  pages={188-94}
}
Human growth inhibitory factor (GIF) is a new metallothionein-related molecule whose expression is markedly reduced in Alzheimer's disease (AD) brain. We have recently isolated a full-length cDNA for human GIF that has a striking homology to metallothioneins (MTs). As an initial step to better understanding of the biological functions of GIF, we have isolated a full-length cDNA for rat GIF. Comparison of the predicted amino acid sequence with that of human GIF revealed a strikingly high… CONTINUE READING

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