Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP).

@article{Higashimoto1992MolecularCO,
  title={Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP).},
  author={Yuichiro I. Higashimoto and J M Simchock and Rodger A. Liddle},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1132 1},
  pages={72-4}
}
A cDNA clone encoding glucose-dependent insulinotropic peptide (GIP) was identified that consisted of 34 bp of 5' untranslated sequence, an open reading frame of 432 bp and 115 bp in the 3' untranslated region. The deduced amino acid sequence revealed a 144 amino acid preprohormone consisting of a 43 amino acid N-terminal extension including a signal peptide, a 42 amino acid hormone, and a 59 amino acid C-terminal extension. Rat GIP differs from the human hormone by two amino acid substitutions… CONTINUE READING