Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.

@article{Nokelainen1996MolecularCO,
  title={Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.},
  author={Pasi A Nokelainen and Terhi Puranen and Hellevi Peltoketo and Mauri Orava and Pirkko Vihko and Reijo Vihko},
  journal={European journal of biochemistry},
  year={1996},
  volume={236 2},
  pages={482-90}
}
The biological activity of certain estrogens and androgens is modulated by enzymes called 17 beta-hydroxysteroid dehydrogenases (17 beta-HSDs), which catalyze the interconversion between less active 17-oxosteroid and more active 17 beta-hydroxysteroid forms. In the present report, we describe cloning of mouse 17 beta-HSD type-1 cDNA from an ovarian library generated from 4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol-(diethylstilbestrol)-tr eated mice, and characterization of the corresponding… CONTINUE READING

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