Molecular cloning of major histocompatibility complex class I cDNAs from the pufferfish Fugu rubripes

@article{Timn1997MolecularCO,
  title={Molecular cloning of major histocompatibility complex class I cDNAs from the pufferfish Fugu rubripes},
  author={Marcos Tim{\'o}n and Greg Elgar and Sonoko Habu and Ko Okumura and Peter Beverley},
  journal={Immunogenetics},
  year={1997},
  volume={47},
  pages={170-173}
}
The mammalian major histocompatibility complex (Mhc) contains a large number of genes encoding for proteins mostly involved in antigen processing and presentation. This clustering could have evolutionary advantages allowing genes with a similar function to be regulated in a coordinated way (reviewed in Trowsdale 1995). The class I a region of the Mhc contains genes encoding the heavy chain of classical class I molecules. These genes are highly polymorphic and strongly and widely expressed… CONTINUE READING

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