Molecular cloning of infectious viral DNA from ecotropic neurotropic wild mouse retrovirus.

@article{Jolicoeur1983MolecularCO,
  title={Molecular cloning of infectious viral DNA from ecotropic neurotropic wild mouse retrovirus.},
  author={Paul Jolicoeur and N Nicolaiew and L DesGroseillers and Eric Rassart},
  journal={Journal of virology},
  year={1983},
  volume={45 3},
  pages={1159-63}
}
Among a mixture of amphotropic and ecotropic murine leukemia viruses (MuLVs) isolated from paralyzed wild mice, only N-tropic ecotropic MuLV, cloned by cell culture techniques, has been shown to induce paralysis after reinjection into susceptible mice (M. B. Gardner, Curr. Top. Microbiol. Immunol. 79:215-239, 1978). The viral DNA genome of one of these neurotropic MuLVs (Cas-Br-E) has been cloned in Charon 21A at the SalI site. One clone, designated NE-8, was studied in more detail. A… CONTINUE READING

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