Molecular cloning of human protein 4.2: a major component of the erythrocyte membrane.

@article{Sung1990MolecularCO,
  title={Molecular cloning of human protein 4.2: a major component of the erythrocyte membrane.},
  author={Lanping Amy Sung and Sung Il Chien and L. S. Chang and K Lambert and S A Bliss and Eric E. Bouhassira and Ronald L. Nagel and Robert S. Schwartz and Anne C. Rybicki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 3},
  pages={
          955-9
        }
}
Protein 4.2 (P4.2) comprises approximately 5% of the protein mass of human erythrocyte (RBC) membranes. Anemia occurs in patients with RBCs deficient in P4.2, suggesting a role for this protein in maintaining RBC stability and integrity. We now report the molecular cloning and characterization of human RBC P4.2 cDNAs. By immunoscreening a human reticulocyte cDNA library and by using the polymerase chain reaction, two cDNA sequences of 2.4 and 2.5 kilobases (kb) were obtained. These cDNAs differ… CONTINUE READING

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