Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.

@article{Dabiri1992MolecularCO,
  title={Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.},
  author={Guissou A. Dabiri and Casey L. Young and Joel Rosenbloom and Frederick Seacrest Southwick},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 23},
  pages={16545-52}
}
Macrophage capping protein (MCP) is a Ca(2+)-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. The human cDNA for MCP has been cloned and sequenced. The derived amino acid sequence predicts a polypeptide of 38.4 kDa. Human MCP expressed in Escherichia coli using a pET12a vector was functionally identical to the native protein purified from rabbit alveolar macrophages with respect to Ca2+ sensitivity and ability to block… CONTINUE READING

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