Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.

@article{Inaoka1995MolecularCO,
  title={Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.},
  author={Tetsuya Inaoka and Graeme Bilbe and Osamu Ishibashi and Katsunari Tezuka and Masayoshi Kumegawa and Tetsuro Kokubo},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={206 1},
  pages={89-96}
}
We have previously cloned a rabbit cDNA clone (OC-2) from an osteoclast cDNA library by the differential screening. OC-2 was found to encode a novel cysteine proteinase, tentatively called cathepsin K, which is predominantly expressed in osteoclasts. By use of a rabbit OC-2 fragment as a probe, its human counterpart was cloned from a cDNA library of osteoarthritic hip bone. The cloned human cDNA (hOC-2) encoded a protein of 329 amino acid residues and its deduced amino acid sequence showed 94… CONTINUE READING

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