Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family.

@article{Batten1997MolecularCO,
  title={Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family.},
  author={Danielle Batten and Kimberly D. Dyer and Joseph B. Domachowske and H F Rosenberg},
  journal={Nucleic acids research},
  year={1997},
  volume={25 21},
  pages={4235-9}
}
We have characterized four novel murine ribonuclease genes that, together with the murine eosinophil-associated ribonucleases 1 and 2, form a distinct and unusual cluster within the RNase A gene superfamily. Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non… CONTINUE READING