Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.

@article{Vanderslice1989MolecularCO,
  title={Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.},
  author={Peter Vanderslice and Charles S. Craik and Jay A. Nadel and George H. Caughey},
  journal={Biochemistry},
  year={1989},
  volume={28 10},
  pages={4148-55}
}
Mast cell tryptase is a secretory granule associated serine protease with trypsin-like specificity released extracellularly during mast cell degranulation. To determine the full primary structure of the catalytic domain and precursor forms of tryptase and to gain insight into its mode of activation, we cloned cDNAs coding for the complete amino acid sequence of dog mast cell tryptase and a second, possibly related, serine protease. Using RNA from dog mastocytoma cells, we constructed a cDNA… CONTINUE READING

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