Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

@article{Miyake1999MolecularCO,
  title={Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.},
  author={Koichi Miyake and Lyn A Mickley and Thomas Litman and Zubing Zhan and Rob Robey and Barbara Cristensen and Mariafiorella Brangi and LeeM. Greenberger and M. Dean and Tito Fojo and Susan E Bates},
  journal={Cancer research},
  year={1999},
  volume={59 1},
  pages={8-13}
}
Reports of multiple distinct mitoxantrone-resistant sublines without overexpression of P-glycoprotein or the multidrug-resistance associated protein have raised the possibility of the existence of another major transporter conferring drug resistance. In the present study, a cDNA library from mitoxantrone-resistant S1-M1-80 human colon carcinoma cells was screened by differential hybridization. Two cDNAs of different lengths were isolated and designated MXR1 and MXR2. Sequencing revealed a high… CONTINUE READING
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