Molecular cloning of cDNAs for two pro-phenol oxidase subunits from the malaria vector, Anopheles gambiae.

@article{Jiang1997MolecularCO,
  title={Molecular cloning of cDNAs for two pro-phenol oxidase subunits from the malaria vector, Anopheles gambiae.},
  author={Huimin Jiang and Ying Wang and S E Korochkina and Helen Bene{\vs} and Michael R. Kanost},
  journal={Insect biochemistry and molecular biology},
  year={1997},
  volume={27 7},
  pages={
          693-9
        }
}
Phenol oxidase exists in insect hemolymph as a zymogen, pro-phenol oxidase (pro-PO), which is activated by specific proteolysis in response to infection or wounding. Phenol oxidase catalyses the synthesis of quinones that polymerize to form melanin deposits, which encapsulate parasites and help to seal wounds. Antibodies to pro-PO from Manduca sexta bound to 76, 72, and 71 kDa polypeptide bands from hemolymph of Anopheles gambiae larvae. This antiserum was used to screen a cDNA library from A… CONTINUE READING

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