Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.

@article{Eggerickx1995MolecularCO,
  title={Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.},
  author={Dominique Eggerickx and J. F. Denef and O Labb{\'e} and Yoshimasa Hayashi and Samuel Refetoff and G. Vassart and Marc Parmentier and Fr{\'e}d{\'e}rick Libert},
  journal={The Biochemical journal},
  year={1995},
  volume={309 ( Pt 3)},
  pages={
          837-43
        }
}
A human gene encoding an orphan G-protein-coupled receptor named ACCA (adenylate cyclase constitutive activator) was isolated from a genomic library using as a probe a DNA fragment obtained by low-stringency PCR. Human ACCA (hACCA) is a protein of 330 amino acids that exhibits all the structural hallmarks of the main family of G-protein-coupled receptors. Expression of hACCA resulted in a dramatic stimulation of adenylate cyclase, similar in amplitude to that obtained with other Gs-coupled… CONTINUE READING
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