Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.

@article{Zain1988MolecularCO,
  title={Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.},
  author={Sayeeda B Zain and Matra Salim and Wen Gang Chou and Elizabeth M. Sajdel-Sulkowska and Ronald E. Majocha and Charles A. Marotta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 3},
  pages={929-33}
}
To gain insight into factors associated with the excessive accumulation of beta-amyloid in the Alzheimer disease (AD) brain, the present studies were initiated to distinguish between a unique primary structure of the AD-specific amyloid precursor mRNA vis a vis other determinants that may affect amyloid levels. Previous molecular cloning experiments focused on amyloid derived from sources other than AD cases. In the present work, we cloned and characterized amyloid cDNA derived directly from AD… CONTINUE READING

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