Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain.

@article{Tsoi1998MolecularCO,
  title={Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain.},
  author={M. Tsoi and Kyung Hee Rhee and David Bungard and Xiao-fang Li and Sandra L. Lee and Roland N. Auer and Jonathan Lytton},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 7},
  pages={
          4155-62
        }
}
We have isolated a novel cDNA clone from rat cerebral cortex encoding a protein of 670 amino acids (NCKX2) that has significant similarity to the 1199-amino acid-long Na/Ca-K exchanger of bovine rod outer segment (NCKX1). NCKX2 transcripts are 10.5 kilobase pairs in length and are expressed abundantly in neurons throughout the brain and with much lower abundance in selected other tissues. The predicted topology of the rat NCKX2 protein is very similar to that of bovine NCKX1, beginning with a… CONTINUE READING

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