Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5.

  title={Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5.},
  author={N. J. Parker and C. G. Begley and Peter J. S. Smith and R. M. Fox},
  volume={37 2},
A novel gene (GOK) has been cloned from human chromosome region 11p15.5 that is believed to contain a gene or genes associated with a number of pediatric malignancies, including Wilms tumor. A 4-kb cDNA has been cloned and it encodes a predicted protein of approximately 84 kDa that could be translated in vitro. Computer analysis predicted that the protein had a signal peptide and may contain a transmembrane helix. Restriction mapping by pulsed-field electrophoresis indicates that GOK is located… CONTINUE READING


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