Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.

@article{Hieshima1997MolecularCO,
  title={Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.},
  author={Kunio Hieshima and Toshio Imai and Ghislain Opdenakker and Jo Van Damme and Jun Kusuda and Hajime Tei and Yoshiyuki Sakaki and Kiyoshi Takatsuki and Rika Miura and Osamu Yoshie and H. Nomiyama},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 9},
  pages={5846-53}
}
Partial overlapping cDNA sequences likely to encode a novel human CC chemokine were identified from the GenBank Expressed Sequence Tag data base. Using these sequences, we isolated full-length cDNA encoding a protein of 96 amino acid residues with 20-28% identity to other CC chemokines. By Northern blot, this chemokine was mainly expressed in liver among various tissues and strongly induced in several human cell lines by phorbol myristate acetate. We thus designated this chemokine as LARC from… CONTINUE READING