Molecular cloning of a novel bone-forming compound: osteoinductive factor.

@article{Madisen1990MolecularCO,
  title={Molecular cloning of a novel bone-forming compound: osteoinductive factor.},
  author={Linda Madisen and Michael G. Neubauer and Gregory D. Plowman and Daniel Rosen and Patricia Segarini and J R Dasch and Alexis Thompson and John Ziman and H L Bentz and Anthony F. Purchio},
  journal={DNA and cell biology},
  year={1990},
  volume={9 5},
  pages={303-9}
}
cDNA clones encoding osteoinductive factor (OIF) have been isolated from a bovine osteoblast library. Sequence analysis of these clones indicated that the 105-amino-acid OIF is synthesized as a larger 299-amino-acid precursor, the carboxyl terminus of which is cleaved to yield the mature protein. Northern blot analysis of bovine osteoblast mRNA revealed two… CONTINUE READING