Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.

@article{Suzuki2000MolecularCO,
  title={Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.},
  author={Takashi Suzuki and Ken-ichi Nishiyama and Akitsugu Yamamoto and Johji Inazawa and Toru Iwaki and Takahiro Yamada and Ichiro Kanazawa and Yoshiyuki Sakaki},
  journal={Genomics},
  year={2000},
  volume={63 2},
  pages={246-54}
}
Expression profiles of thousands of genes (cDNAs) were analyzed in sporadic Alzheimer disease (AD)-affected brains in comparison with normal subjects by using the high-density cDNA filter method and differential display analysis. Among 31 differentially expressed genes, one gene was found to be markedly depressed in AD-affected brains. A full-length (or nearly full-length) cDNA of the gene was isolated and sequenced. The cDNA turned out to be an orthologue of rat Nap1. The gene was thus… CONTINUE READING