Molecular cloning of a levocabastine‐sensitive neurotensin binding site

  title={Molecular cloning of a levocabastine‐sensitive neurotensin binding site},
  author={P. Chalon and N. Vita and M. Kaghad and M. Guillemot and J. Bonnin and B. Delpech and G. le Fur and P. Ferrara and D. Caput},
  journal={FEBS Letters},
  • P. Chalon, N. Vita, +6 authors D. Caput
  • Published 1996
  • Biology, Medicine
  • FEBS Letters
  • A search for sequences homologous to the neurotensin receptor cDNA in a rat hypothalamic library has identified a novel neurotensin receptor (NTR‐2). The 1539 bp cDNA encodes a 416 amino acid protein and shows highest homology to the previously cloned neurotensin receptor (NTR‐1) (64% homology and 43% identity). Binding and pharmacological studies demonstrate that NTR‐2 expressed in COS cells recognizes neurotensin (NT) with high affinity as well as several other agonists and antagonists… CONTINUE READING
    236 Citations
    Mutagenesis and Modeling of the Neurotensin Receptor NTR1
    • 67
    • PDF
    Neurotensin and neurotensin receptors.
    • 461
    Differential Binding Profile and Internalization Process of Neurotensin via Neuronal and Glial Receptors
    • 63
    • PDF
    The 100-kDa Neurotensin Receptor Is gp95/Sortilin, A Non-G-Protein-coupled Receptor*
    • 357
    • PDF
    Neurotensin Agonist Induces Differential Regulation of Neurotensin Receptor mRNA
    • 49
    • PDF


    Identification of a polymorphism in the human neurotensin receptor gene.
    • 40