Molecular cloning of a levocabastine‐sensitive neurotensin binding site

@article{Chalon1996MolecularCO,
  title={Molecular cloning of a levocabastine‐sensitive neurotensin binding site},
  author={P. Chalon and N. Vita and M. Kaghad and M. Guillemot and J. Bonnin and B. Delpech and G. le Fur and P. Ferrara and D. Caput},
  journal={FEBS Letters},
  year={1996},
  volume={386}
}
  • P. Chalon, N. Vita, +6 authors D. Caput
  • Published 1996
  • Biology, Medicine
  • FEBS Letters
  • A search for sequences homologous to the neurotensin receptor cDNA in a rat hypothalamic library has identified a novel neurotensin receptor (NTR‐2). The 1539 bp cDNA encodes a 416 amino acid protein and shows highest homology to the previously cloned neurotensin receptor (NTR‐1) (64% homology and 43% identity). Binding and pharmacological studies demonstrate that NTR‐2 expressed in COS cells recognizes neurotensin (NT) with high affinity as well as several other agonists and antagonists… CONTINUE READING
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