Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

@article{Dandrea1995MolecularCO,
  title={Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.},
  author={Alan D'andrea and Chi Chang and Karin Franz-Bacon and Terri Mcclanahan and Joseph H. Phillips and Lewis L. Lanier},
  journal={Journal of immunology},
  year={1995},
  volume={155 5},
  pages={2306-10}
}
The expression of certain MHC class I allotypes by potential target cells can inhibit NK cell-mediated cytotoxicity. We recently identified the NKB1 surface Ag, expressed on T and NK cell subsets, as a putative inhibitory receptor for HLA-B class I molecules possessing the Bw4 serologic epitope. NKB1 is a 70-kDa glycoprotein that after deglycosylation migrates as a 50-kDa protein as determined by SDS-PAGE. A cDNA encoding the NKB1 receptor was cloned from a NKB1+T cell cDNA library by… CONTINUE READING