Molecular cloning of IGF-1 and IGF-1 receptor and their expression pattern in the Chilean flounder (Paralichthys adspersus).

@article{Escobar2011MolecularCO,
  title={Molecular cloning of IGF-1 and IGF-1 receptor and their expression pattern in the Chilean flounder (Paralichthys adspersus).},
  author={Sebasti{\'a}n Escobar and Eduardo N. Fuentes and Erika Poblete and Juan Antonio Vald{\'e}s and Diego Safian and Ariel E Reyes and Marco Alvarez and Alfredo Molina},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2011},
  volume={159 3},
  pages={140-7}
}
Insulin-like growth factor-1 and insulin-like growth factor-1 receptor (IGF-1 and IGF-1R) play main roles in vertebrate growth and development. In fish, besides contributing to somatic growth, both molecules exhibit pleiotropic functions. We isolated complete cDNAs sequences encoding for both IGF-1 and IGF-1R in the Chilean flounder by using RT-PCR and rapid amplification of cDNAs ends (RACE) techniques. We analyzed gene expression in pre-metamorphic larvae and different organs of juvenile fish… CONTINUE READING

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