Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

@article{Akira1994MolecularCO,
  title={Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway},
  author={S. Akira and Y. Nishio and M. Inoue and Xue-jie Wang and Shi We and T. Matsusaka and Kanji Yoshida and T. Sudo and M. Naruto and T. Kishimoto},
  journal={Cell},
  year={1994},
  volume={77},
  pages={63-71}
}
Acute-phase response factor (APRF) is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. We report here the purification and cloning of APRF. APRF exhibits a 52.5% overall homology at the amino acid level with p91, a component of the interferon (IFN)-stimulated gene factor 3 complexes. The cloned APRF protein is tyrosine phosphorylated and translocated into the nucleus in response to IL-6, but not… Expand
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  • Biology, Medicine
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Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1
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