Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.

@article{Minakami1994MolecularCA,
  title={Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.},
  author={R. Minakami and F. Katsuki and T. Yamamoto and K. Nakamura and H. Sugiyama},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 3},
  pages={
          1136-43
        }
}
We previously reported that a variant with extra amino acids exists in rat metabotropic glutamate receptor subtype 5 (mGluR5) and that the identical extra sequence also exists in the human mGluR5 cDNA. We herein report the complete sequence and the functional expression of two isoforms of mGluR5 from the human brain. The deduced amino acid sequence of the large extracellular domain is extremely well conserved between rat and human mGluR5 (98.6%) which suggests that the amino-terminal region of… Expand
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