Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.

@article{Minakami1994MolecularCA,
  title={Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.},
  author={Reiko Minakami and F Katsuki and T. Yamamoto and Kazuto Nakamura and Hiroyuki Sugiyama},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 3},
  pages={
          1136-43
        }
}
We previously reported that a variant with extra amino acids exists in rat metabotropic glutamate receptor subtype 5 (mGluR5) and that the identical extra sequence also exists in the human mGluR5 cDNA. We herein report the complete sequence and the functional expression of two isoforms of mGluR5 from the human brain. The deduced amino acid sequence of the large extracellular domain is extremely well conserved between rat and human mGluR5 (98.6%) which suggests that the amino-terminal region of… 
The Expression of Two Splice Variants of Metabotropic Glutamate Receptor Subtype 5 in the Rat Brain and Neuronal Cells During Development
TLDR
An extracellular application of trans‐d,l‐1‐amino‐1,3‐cyclopentanedicarboxylate on the neuron‐like P19 cells induced intracellular Ca2+ mobilization, thus suggesting that the cells could express functional mGluR(s) coupled to phospholipase C and other components that could mediate the signal transduction pathway.
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