Molecular cloning and structural characterization of the human histidase gene (HAL).

  title={Molecular cloning and structural characterization of the human histidase gene (HAL).},
  author={M. Suchi and H. Sano and H. Mizuno and Y. Wada},
  volume={29 1},
  • M. Suchi, H. Sano, +1 author Y. Wada
  • Published 1995
  • Biology, Medicine
  • Genomics
  • Histidase (EC is a cytosolic enzyme that catalyzes the nonoxidative deamination of histidine to urocanic acid. Histidinemia, resulting from reduced histidase activity as reported in Cambridge stock his/his mice and in humans, is the most frequent inborn metabolic error in Japan. The histidase chromosomal gene (HAL) was isolated from a lambda EMBL-3 human genomic library using the human histidase cDNA as a probe. Restriction mapping and Southern blot analysis of the isolated clones… CONTINUE READING
    41 Citations
    Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene
    • 7
    Molecular cloning of chicken hepatic histidase and the regulation of histidase mRNA expression by dietary protein.
    • 2
    Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells.
    • 13
    • PDF
    AT-AC Pre-mRNA Splicing Mechanisms and Conservation of Minor Introns in Voltage-Gated Ion Channel Genes
    • 154
    • PDF