Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I.

@article{Jakobi1996MolecularCA,
  title={Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I.},
  author={R. Jakobi and Ching Jiunn Chen and Polygena T. Tuazon and Jolinda A. Traugh},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 11},
  pages={6206-11}
}
The serine/threonine protein kinase PAK I (p2l-activated protein kinase), a ubiquitous multipotential protein kinase of 58-60 kDa, has been shown to have cytostatic properties. Data from our laboratory show that PAK I is highly active in oocytes and quiescent and serum-starved cells, and injection of active PAK I into one blastomere of two-cell frog embryos inhibits cleavage of the injected blastomere. To clone the cDNA encoding PAK I, purified peptides from rabbit PAK I were sequenced… CONTINUE READING